Metroid Prime

Metroid Prime is the nineteenth issue of the series.

Plot
Samus and Oveur arrive at the Impact Crater. They suddenly find a huge creature called Metroid Prime, but Samus, using "multiple weapon pwnage", destroys it, or so it seems-instead, it reforms as a giant tentacled creature. The new incarnation rips Oveur's head off (Samus notes that he'll "just reincarnate") and then attacks Samus.