Samus and the Wii is a special issue of the series. It is a parody of the unusual design of the Nintendo Wii and its remote.
Samus tries to teach readers how to play Metroid Prime 3: Corruption. However, it quickly becomes apparent that she herself has no idea how to use the Wii remote, and eventually throws it down in anger. Oveur then comes in and plays the game perfectly fine, saying that the remote "works like a charm".